报告人简介:
RESEARCH INTEREST:Cancer cells couldpredominantly produce energy by glycolysis even in the presence of oxygen. Thisalternative metabolic characteristic is known as the “Warburg Effect.” Althoughthe exact mechanisms underlying the Warburg effect are unclear, recent progressindicates that energy metabolism pathway of cancer cells could be a criticaltarget for drug discovery. The major research focus in my lab is todiscover anticancer compounds from traditional Chinese medicine (TCM) bytargeting cancer cells’ characteristic Warburg Effect. In order to achieve thisgoal, we are actively engaged in screening TCM for anticancer activity byinvestigating a number of onco-proteins and tumor suppressors, including thePI3K/Akt/mTOR signaling pathway, Myc, hypoxia-inducible factor and p53, whichare involved in the regulation of the metabolic adaptation.
EDUCATION
1998 Ph.D., Graduate School of NagoyaUniversity School of Medicine, Nagoya, Japan
1988 M.D., Nanjing Medical University, Nanjing, China
PROFESSIONAL EXPERIENCE
Apr2014-Current Professor, Division ofPathology, Department of Biomedical Sciences, College of Life and HealthSciences, Chubu University, Aichi, Japan
Apr 2006- Mar2014 Associate Professor, Division of Pathology, Department ofBiomedical Sciences, College of Life and Health Sciences, Chubu University,Aichi, Japan
Oct 2001-Mar2006 Assistant Professor, Department of Biochemistry, AichiMedical University, Aichi, Japan
Apr 2000-Sep2001 Postdoctoral Fellow, National Institute for Longevity Sciences,NCGG, Japan
Apr 1998-Mar1999 Research Fellow, Department of Pathology, NagoyaUniversity School of Medicine, Nagoya, Japan
Sep 1989–Jun1993 Surgeon, the Second Affiliated Hospital of NanjingMedical University, Nanjing, China